Sentence examples for maintaining a stem from inspiring English sources

Upregulation of EZH2 expression in tumors appears to correlate with disease progression by maintaining a stem cell-like phenotype.

Asymmetric cell divisions are a major route for stem cells to give rise to differentiated cells while simultaneously maintaining a stem cell population.

This expression pattern is consistent with reported roles for Wnt signaling in maintaining a stem cell pool and in Paneth cell differentiation.

ΔNp63α, the isoform produced by combination of the second promoter with the longest C-terminal splice variant, plays an important role in the development of stratified epithelial tissues including skin by maintaining a stem cell population in the basal layer (Senoo et al., 2007).

Since recently, the role of EpCAM in maintaining a stem cell phenotype in HCC and ICC is being elucidated but our studies, as well as others provide evidence for its role in the promotion of proliferation, migration and invasion potential in cells with activated Wnt/β-catenin signaling [ 60, 91, 128].

BM MSCs treated with a low FasL dose (0.5 ng/ml) proliferated more rapidly than untreated cells without undergoing spontaneous differentiation or apoptosis, whereas higher doses (25 ng/ml) induced significant though not massive BM MSC death, with surviving cells maintaining a stem cell phenotype.

Instead of maintaining a stem-cell-like state, a restriction of epigenetic plasticity induced by widespread hypermethylation could act as a check on cancer progression.

Sox1, Sox2 or Sox3 maintain a stem cell-like state [49], [50], and Sox9 alters the potential of stem cells from neurogenic to gliogenic [51], whereas Sox10 is essential for terminal oligodendrocyte differentiation [52].

However, other studies have indicated that CXCR4 is highly expressed on cancer stem cells, and its activation maintains a stem cell population in tamoxifen-resistant breast cancer [ 29].

Stem cells are capable of renewing themselves to maintain a stem cell pool as a preserved cell source for tissue homeostasis, while they can also differentiate into mature cells to carry out the function of a specific tissue.

These data demonstrate that GSCs are capable of utilizing different modes of cell division to maintain a stem cell population and GSCs are maintained mainly by symmetric, not by asymmetric cell divisions.