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The analgesia and affect improvements were maintained with repeated virtual reality use over multiple therapy sessions.
The magnitude of the analgesic effect is clinically meaningful and is maintained with repeated use.
Furthermore, using placebo-controlled data, we show that the antidepressant response to NMDA channel blockers can be maintained with repeated and intermittent drug administration.
Anesthesia was maintained with repeated boli of Saffan® (alfaxadone 0.9%% and alfadadolone acetate 0.3 %; Schering Plough, Welwyn Garden City, UK) and muscle relaxation was achieved with cis-atracurium besylate 0.5 mg kg−1 (GlaxoSmithKline, Dublin, Ireland).
Sedation was maintained with repeated doses of 10 to 20 mg propofol.
The current study has shown that these acute effects of l-amphetamine are maintained with repeated daily dosing over 14 days, with no evidence of tolerance developing.
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Anesthesia was maintained with isoflurane, fentanyl (repeated bolus doses, as directed, as directed by cardiovascular stability, at the discretion of attending anesthesiologist) and non-depolarizing muscle relaxants (vecuronium or pancuronium) in both study groups.
Additionally, in at least Polistes wasps, markers of identity are disproportionally prominent in social taxa, suggesting that in some cases they may be naturally selected and maintained in lineages with repeated interaction and the need to differentiate conspecifics [24].
In addition, achievement of EULAR good response at week 24 was maintained or improved with repeated courses of rituximab [ 41].
This pilot study demonstrates the feasibility of maintaining subject compliance with repeated data collection during an acute pain episode.
If membrane GABA reuptake is required for supplying GABA for vesicular exocytosis, inhibiting GATs should prevent DA neurons from maintaining GABA release with repeated stimulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com