Sentence examples for maintained under hypoxia from inspiring English sources

Here, we investigate the role of mTOR signaling in the regulation of HIF-1α stability in primary GBM-derived cells maintained under hypoxia (2% oxygen).

We sought to investigate if a progressive time dependent exposure of GBM cells, that have been constantly maintained under hypoxia (2% oxygen), to an acute 20% oxygen tension, was promoting Akt/mTOR signaling pathway activation.

Moreover, FKBP38, which has been recently described as a PHD2 protein modulator [19], was down-regulated both by high oxygen exposure and BMP2 treatment in GBM cells maintained under hypoxia.

In this study we investigated the role of mTOR signaling in the regulation of HIF-1α stability in primary GBM-derived cells compared to normal SVZ-derived cells, maintained under hypoxia, evaluating the effects mediated by acute high oxygen exposure and BMP2.

Here we investigate the role of mTOR signaling in the regulation of HIF-1α stability in primary GBM-derived cells maintained under hypoxia (2% oxygen), condition resembling their physiological microenvironment [9], evaluating the effects mediated by an acute raise of oxygen tension and by BMP2 treatment.

Etiolated seedlings maintained under hypoxia were able to complete hook opening when exposed to light but had defective unfolding and greening of cotyledons, indicating that oxygen is required for the complete response to light.

Using this system, we generated T98G-DDS10 cexposedposed to 10 or more cycles of hypoxia and nutrient deprivation stress cycles, because most cancer cells including T98G cells cannot be maintained under the prolonged hypoxia and nutrient starvation DDS for longer than 72 h in vitro.

Interestingly, tissues maintained under periods of hypoxia increase their intracellular calcium [ 18], an effect that is worsened when the activity of the PMCA is decreased [ 17].

Nucleus pulposus (NP) cells reside in a hypoxic environment in vivo, while the mechanisms of how NP cells maintain survival under hypoxia are not clear.

Analyses of mTOR downstream targets, revealed a time dependent increase of Stat3 (Ser727) and p70S6K (Thr389) activation following BMP2 treatment, and these effects were decelerated and decreased by maintaining cells under hypoxia (Figure 4A,E,F), and this occurred transiently also in normal cells (Figure S1A,E,F).

To confirm that EC154 and LBH589 similarly maintain efficacy under hypoxia, UMCRC2 and 786-O cells were exposed to hypoxia [ 25, 71] for 16 h in either the presence or absence of these agents.