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These models are powerful because they capture higher order correlations induced by mutations evolving under constraints and help quantify the connections between protein sequence, structure, and function maintained through evolution.
The structure of U6 ISL is highly similar to the catalytic stem-loop structure of Group-II ribozyme [13], [47] and it appears that this structure has been maintained through evolution of the splicing mechanism [48], [49].
Another phylogenetic analysis of catalytic domain sequences from various organisms showed that sequences of animal, fungi, and bacteria belong to different lineage; however, chitinase genes from lepidopteran insects and baculoviruses originated from bacteria and were maintained through evolution since they transferred laterally [62].
Feedback allosteric inhibition of metabolic enzymes is one of the most efficient mechanisms maintained through evolution for control of flux through biochemical pathways.
We show here that one aspect of gene context, the amount of potential upstream regulatory sequence maintained through evolution, is highly predictive of both molecular function and biological process in diverse fungi.
However, this result is not a surprise since these patterns actually correspond to very precise functional signatures which are therefore expected to be strongly maintained through evolution in order keep their functional activities.
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It is therefore difficult to determine how conservation has been maintained through microsporidian evolution, and impossible to identify whether certain regions are more prone to genomic stasis.
It is unlikely that the envelope gene has been maintained as a result of retroviral replication through an extracellular cycle, since the sites of integration have been maintained through simian evolution.
Further, that the four JPs are conserved in both invertebrate and vertebrate TR orthologue genes suggest that the gene organization of vertebrate TR genes is ancient and has been maintained through out evolution of TRs.
First, recall the original mutualistic conundrum: natural selection should favor the evolution of cheaters, so how is it that this mutualism can be maintained through millions of years of evolution?
The alteration of gene expression cascades due to the activity of the fusion proteins may be essential for the DNA hypomethylation pattern in patients with t(1 19) and the other translocations, which presumably occur in the early stages of leukemic transformation and are maintained through cellular division and clonal evolution.
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maintained through day
maintained through proliferation
maintained through remethylation
maintained through violence
maintained through hypervigilance
maintained through business
maintained through bullying
maintained through p60
maintained through speech
maintained through market
maintained through fear
maintained through water
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maintained through evolutionary
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