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An estimated 43% of patients who responded to therapy maintained their response at 24 months.
Most (70/91; 77%) of the PASI 75 responders at week 12 maintained their response at week 24.
A total of 24% of responders maintained their response at 5 years and 15% at 7 years without any further therapy.
Notably, dose modification did not appear to compromise response, as 8 of the 17 patients with clinical benefit were dose adjusted, and maintained their response.
Out of the N=129 placebo induction therapy responders, a total of R=46 also maintained their response during placebo maintenance therapy.
A numerically greater proportion of week 96 responders (plasma viral load less than 50 copies/ml) maintained their response at week 240 in the MVC b.i.d.
Similar(51)
Performance in reversal learning is indexed by the number of perseverative errors committed when participants maintain their response towards previously reinforced stimulus in spite of negative reward.
Thus, IL neurons may maintain their response to the tone as if the conditioning contingency is still in place.
For any given competitive interaction between AM tones there could be units in any BP range of the map whose responses to its optimal AM tone can be suppressed as long as the competing AM are different (losers) and other units that maintain their response to an optimal AM irrespective of the presence of other competing AM tones (winners).
In addition, further research is warranted in CAPS patients who have the V198M mutation to understand why they require higher doses of canakinumab or more frequent administration to maintain their response.
Thus, it is possible that patients with particular mutations such as the V198M mutation may require higher doses of canakinumab or more frequent administration to maintain their response and have contributed to the lower value for time-to-relapse for children reported for this study.
More suggestions(15)
maintained their grip
maintained their dominance
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maintained their independence
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maintained their loyalty
maintained their advantage
maintained their intensity
maintained their integrity
maintained their pace
maintained their silence
maintained their grandeur
maintained their poise
maintained their value
maintained their composure
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