Sentence examples for maintained the stem from inspiring English sources

NSCs proliferated and maintained the stem cell state, validated by Nestin staining (Figure 3C).

Therefore, the number of CB hematopoietic stem/progenitor cells (HSPCs) should be increased while maintaining the stem cell characteristics.

Stem cells are in close contact with a special microenvironment, called the stem cell niche, which is crucial for maintaining the stem cell identity and the potential to self-renew (Li & Xie 2005).

However, the therapeutic potential of hMSCs cannot be realized without gaining a more complete understanding of the in vitro culture parameters that can best maintain the stem cell phenotype and multipotency during expansion.

This reversible switch from activation to dormancy has also been observed with hematopoietic stem cells as they maintain the stem cell pool following bone marrow injury [43].

Some of the earlier studies have pointed out the role of apoptosis cascade in maintaining the stem cell compartment [10], [11].

Analysis of the Oct4 gene list revealed an important emerging theme; mechanisms to actively repress apoptotic pathways are involved in maintaining the stem cell state.

The spermatogonial stem cells pass through several mitotic divisions after which they give rise to primary spermatocytes which enter meiosis; alternatively, the stem cells continue to divide as spermatogonia thereby maintaining the stem cell pool.

The high frequency at which apoptotic genes were negatively correlated to Oct4 and anti-apoptotic genes were positively correlated to Oct4 implies that 'anti-apoptosis' is an important theme for maintaining the stem cell state.

Under steady-state conditions the expression of p21 is enriched in HSCs relative to committed hematopoietic progenitors [36], maintaining the stem cell self-renewal capacity perhaps by regulating their cell cycle entry [37].

The molecular mechanism(s) of SALL4 in maintaining the stem cell properties involve at least two processes: SALL4 activates Oct4 as a transcriptional factor, and interacts with Nanog by forming a protein-protein complex.