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Moreover, compounds 21, 25, and 30 maintained the functional profiles (EC50 and IC50 values of 15 50 nM) of the parent azetidine-containing compounds 3 and 4 in the 86Rb+ ion flux assays.
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Observations of localization of CSB protein in mitochondria and its role in the repair of mitochondrial oxidative DNA damage further add a new dimension to the multitude of complex cellular functions of CSB in maintaining the functional integrity of mitochondria.
We initially hypothesized that Pnt might function in parallel with Btd to maintain the functional identity of a type II neuroblast.
However, along the margins there are long, dense fringes of hairs that maintain the functional wing area.
Thus, MuSK and AChR together maintain the functional and structural integrity of the postsynaptic architecture and prevent axon growth.
The results showed that orchard-based conservation was an efficient way in maintaining the functional connectivity, which mainly contributed to the intrapatch connectivity and species dispersal flux.
Overall, 2% SDS, for 1 or 2 h, appeared to be the most effective agent for cartilage decellularization, as it resulted in decellularization while maintaining the functional properties.
Our results highlight the value of urban forest remnants in maintaining the functional capacity of urban landscapes for biodiversity by protecting hollow-bearing trees as habitat resources.
There is an urgent need to conserve or restore critical habitats outside of protected areas to maintain the functional connectivity of habitat networks.
Findings in desired scenario were a strong development of public transport and a coordination between spatial development and transport system, high parking fees, congestion pricing and maintaining the functional role of Central Business District Area.
Based on homology modeling of the KCNQ1 channel pore region, we speculate that the proline residue at position 320 limits flexibility of the outer pore and is required to maintain the functional architecture of the selectivity filter/pore helix arrangement.
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