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Overall, simplification of the lead compound 1 into compound 12b has maintained the activity, while facilitated the synthetic advantages.
A majority of these derivatives maintained the activity of azithromycin against susceptible Streptococcus pyogenes and all the compounds demonstrated remarkably improved activity compared with the references against all the three phenotypes of resistant Streptococcus pneumoniae.
Replacement of the two methyl groups with two chlorine atoms maintained the activity toward Leukemia cell (CCRF-CEM, GI 77%) and selectively enhanced the activity against COLO 205 attaining a LD50 in the μM range and against SW-620 a GI of 77%.
Similarly, STAT5A1*6 also maintained the activity of BCS cells albeit to slightly lesser degree (Fig. 3C).
Gazarian et al. [ 31] described a tobacco peroxidase that oxidizes VA at pH 1.8, although it maintained the activity only for 15 minutes, and similar activities for shorter time periods have been reported for other plant peroxidases [ 32].
We were also not able to identify a specific size fraction that maintained the activity, although generally the activity appeared in all fractions greater than 30 kDa (data not shown).
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VE maintained the activities of membrane bound enzymes at near normal values and thus preserving mitochondrial membrane integrity and protected enzyme activities from oxidation by free radicals [ 61].
Furthermore, CuCo2O4/NF presents an excellent long-term electrochemical durability maintaining the activity at overpotential of 240 mV for 10 h.
In our study, although the POD activity decreased in P. litchii-inoculated fruits, the CTE treatment could largely maintain the activity during storage.
Concerning temperature stability, the enzyme showed good stability at 40 °C and 45 °C, maintaining the activity during 60 min of incubation (Fig. 4b).
We also describe our continuous efforts in achieving a label-free detection without non-specific binding while maintaining the activity and stability of immobilized biomolecules.
More suggestions(15)
retain the activity
maintained the flava
maintained the form
maintained the faith
maintained the program
maintained the tradition
maintained the use
maintained the site
maintained the separation
maintained the ability
maintained the ban
maintained the status
maintained the epithelial
maintained the base
maintained the database
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