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In addition, at least one mAB maintained specificity for anandamide compared to two very closely related fatty acid amide molecules.
The sensitivity of such clinical predictive rule was markedly improved (66%) with a maintained specificity (87%) by taking into account the presence of Candida colonization at time of its assessment [74].
All 58 undiluted negative specimens from persons without Cryptococcus spp. infection remained negative by thermal contrast, which demonstrated maintained specificity.
The sensitivity of such clinical predictive rule was markedly improved (66%) with a maintained specificity (87%) by taking into account the presence of Candida colonization at time of its assessment [ 74].
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Reported antigen MAL5 was recognized with IgA having 82.6% sensitivity with maintaining specificity up to 54.5% which is the best among all these specific antigens.
Sensitivity needs to be increased while maintaining specificity for actual use in an environment with varying antibiotic prescription practices.
We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity.
However, some cross-amplification did occur at an annealing temperature of 60 °C (lower than the optimal 63 °C) or late in PCR cycling (i.e., Cq values greater than 35) indicating the need to adhere to stringent cycling conditions to maintain specificity.
Meanwhile, selection acting to maintain specificity for a different hormone that was structurally similar to aldosterone meant that once aldosterone arose, it could bind to the mineralocorticoid receptor which remained similar to the ancestral form (a process Bridgham et al. 2006 call "molecular exploitation"; Fig. 1A).
The 3.5 score threshold was used to maintain specificity, although at the cost of sensitivity, in the target prediction algorithm.
Such complexity is likely key to maintaining specificity given the multitude of stimuli which use calcium to mediate their physiological effects.
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