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However, despite the initial clinical improvement after treatment, many patients relapse on discontinuing treatment once maintained remission of the disease has been achieved.
For patients who are not eligible for a stem cell transplant, immunotherapy with a combination of histamine dihydrochloride (Ceplene) and interleukin 2 (Proleukin) after the completion of consolidation has been shown to reduce the absolute relapse risk by 14%, translating to a 50% increase in the likelihood of maintained remission.
All patients that maintained remission (patients 3, 4, and 5) maintained a measurable functional response to PR1 at all times sampled after IFN withdrawal.
43% patients achieved and maintained remission and had steroids withdrawn.
Figure 1 shows that after 54 weeks, 11 of the 23 responders had maintained remission (47.8%).
In the present case, the patient achieved and maintained remission for more than 6 months.
Similar(21)
Mesalazine is widely used systemically or topically to achieve and maintain remission in inflammatory bowel disease.
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.
Azathioprine or methotrexate are also used as the sole therapy to maintain remission in these diseases, and their dose is optimized based on the weight of the patient.
The prodrug azathioprine is primarily used for maintaining remission in inflammatory bowel disease, but approximately 30% of the patients suffer adverse side effects.
Gerss, J. et al. Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study.
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