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The maintained parameters for the fittings are displayed in Table 1. Figure 1 Production of the mycotoxins tenuazonic acid (TA) ( a ), alternariol (AOH) and alternariol monomethylether (AME) ( b ) and consumption of the nutrients glucose, nitrate and ammonium ( a, b ) with A. alternata DSM 12633 in a 2 L bioreactor.
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(2) Different potentials for maintaining parameter difference are found for different airflow patterns.
The initial labeling proportions amongst the two partitions are obtained from the day 10 predictions in stage 2 so that we maintain parameter integrity between the three different estimate regions.
It might be due to the capability to maintain parameter diversities with higher dS values.
In each iteration process, we have newly implemented a calculation using a parameter called dS to maintain parameter diversities.
These results suggest the importance of maintaining parameter diversities in performing CNM using the dS algorithm, while further investigations should be needed to rationally determine feasible dS values in other cases.
After improvements in the original CNM algorithm to maintain parameter diversities, a feasible solution space was successfully estimated for 55 or 56 parameters in the irinotecan PBPK model, within ten iterations, 3000 virtual samples, and in 15 minutes (Intel Xeon E5-1620 3.60GHz × 1 or Intel Core i7-870 2.93GHz × 1).
We examined the effect of dS values on the convergence in this system, which was newly introduced in the algorithm to maintain parameter diversities as explained in the Methods section, and the calculation with dS of 0 is identical to the original CNM algorithm.
Animals of Group 1 maintained its parameters within the normal ranges.
In contrast, the Sgce-null and Sgca-null mice maintained normal parameters at this age.
Interestingly, the administration of EDTA before Isc and Isc/R, maintained both parameters at physiological levels (Fig. 1), thus suggesting a protective role of EDTA toward the renal filter capacity.
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