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The T category has maintained its prognostic relevance throughout these changes [ 3].
Moreover, in the multivariate analysis HER3 maintained its prognostic value for OS.
The expression of ALDH1A1 maintained its prognostic value in predicting shorter OS and RFS in all of these subgroups for except OS in T1/T2 subgroup (P = 0.054).
Interestingly, additional multivariate analysis further demonstrated that GP88 expression maintained its prognostic value even when adjusted to combined indicators, such as age, ethnicity and tumor characteristics simultaneously.
Only the PIT prognostic index maintained its prognostic value when including mPIT, KI67 and PIT in the Cox multivariate study (Supplementary Table 7).
When we introduced not only tumor stage but also biological characteristics into the multivariate analysis, the method of detection maintained its prognostic value (RR = 0.42; CI = 0.19-0.93).
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Despite the association between KPNA2 and outcome in univariate analysis, it did not maintain its prognostic value when other well-established prognostic variables were included.
In contrast, MPS maintains its prognostic power [ 130].
Apparently, as demonstrated by previous studies, this variable fails to maintain its prognostic significance when included in multivariable models [ 4, 6].
In Cox multivariate analysis KRAS mRNA expression did not maintain its prognostic significance (HR=1.32, 95% CI: 0.9 2.0, P=0.17) adjusted for age, histological type, grade and FIGO stage.
In this analysis, the GD2-IC status seemed to maintain its prognostic role independently from both Myc-N amplification and 1p deletion.
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