OCT 3/4 is expressed in pluripotent cells of the inner cell mass of a blastocyst and, in contrast to the differentiating somatic cells, its expression is maintained in primordial germ cells.
In mice, SOX2 acts in conjunction with OCT 3/4 and its expression is maintained in primordial germ cells until they migrate, colonise the gonad, and become specified as pre-spermatogonia or oogonia, whereupon SOX2 is down regulated.
Although Rif1 is highly expressed in totipotent and many pluripotent cell types (zygotes, cleaving embryos, ESC lines maintained in vitro, primordial germ cells), it is downregulated in the ICM of the blastocyst [ 54].
It is possible that Tsc adjusts mTORC1 activity in oocytes to an optimal level, so that the pool of primordial follicles is maintained in a dormant but surviving condition.
To maintain the normal length of female reproductive life, the majority of primordial follicles must be maintained in a quiescent state for later use (1– 3).
Promoting resolution of sister DNA molecules might thus be the primordial function of SMC-kleisin complexes, which has been evolutionarily maintained in prokaryotic condensin, as well as condensin in eukaryotes.
The maintenance of structural functional characteristics of vascular tissues indicates that their primordial role in plants, i.e. conducting water and solutes (Buvat 1989), is maintained in galls.
Anti-Müllerian hormone (AMH) is produced by granulosa cells in primary to small antral follicles of the adult ovary and helps maintain primordial follicles in a dormant state.
Throughout my journey in different regions of Peru I've seen a lot of color but color can be found in all the different cultures of the world, when they maintain their primordial essence.
In post-implantation embryos, Stella is specifically expressed in primordial germ cells (PGCs), and its expression is maintained until E14.5 in the female and E15.5 in the male (Payer et al., 2003; Saitou et al., 2002; Sato et al., 2002).
The exact roles of OCT 3/4, SOX2 and NANOG in primordial germ cells is currently unknown, but as they are important for maintaining pluripotency and proliferation in embryonic stem (ES) cells, it is considered likely that they also maintain pluripotency in germ cells and prevent their differentiation.
