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Vascular disease risk factors were associated with higher healthcare costs across all countries except Germany, but associations were only maintained in multivariate analysis for the UK (1.2-fold increase, 95 % CI 1.0 1.4) and Spain (1.3-fold increase, 95 % CI 1.0 1.7).
Presence of pain-related comorbidities were associated with higher cost across all countries, but these associations were only maintained in multivariate analysis for the UK (1.4-fold increase, 95 % CI 1.1 1.7), France (1.5-fold increase, 95 % CI 1.2 1.8), and Germany (1.8-fold increase, 95 % CI 1.5 2.3).
The relationship between age and reported acts of aggression was not maintained in multivariate analysis.
In contrast, SUVmax was predictive of both PFS and OS and this effect was maintained in multivariate COX regression model.
Although injection drug use remains the main risk factor for HCV seropositivity as reported by other studies (15 ), differences by geographic origin are maintained in multivariate analyses.
Other individual components of APRI or FIB-4 such as AST level and platelet count were not significantly maintained in multivariate analysis.
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Statistical significance of psychiatric comorbidities was not maintained in the multivariate models for France or Spain.
The patterns of co-occurrence among the physical, mental and behavioral health problems were generally maintained in the multivariate models in Table 3.
This association was not maintained in the multivariate analysis.
In addition, the prognostic significance of EGFR for OS was maintained in the multivariate analysis.
Variables were maintained in the multivariate GLM models for p < 0.05.
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