Sentence examples for maintained efficacy from inspiring English sources

during 6 months and a maintained efficacy over 45 months against clinical and severe disease (30 and 39%, resp).

Although definitive exposure−efficacy relationships are yet to be established, the increased cumulative exposure potentially explains the maintained efficacy of peginterferon beta-1a despite its reduced dosing frequency.

In a subsequent 40-week extension designed to assess long-term safety and tolerability, asenapine was well tolerated and maintained efficacy at a level comparable to olanzapine [ 17].

Some combinations that were not synergistic also maintained efficacy with reduced level of standard cytotoxic drugs (DRI > 1) when combined with Nutlin-3a.

Ongoing adalimumab treatment was associated with maintained efficacy through 4 years, using as-observed, LOCF or the more conservative hNRI imputation method.

The edoxaban 30-mg once-daily dose maintained efficacy (HR 0.73; 95 % CI 0.42 1.26) and preserved safety (HR 0.62; 95 % CI 0.44 0.86) compared with warfarin therapy [ 19].

These findings are of high relevance to gene therapies for diseases with early lethality10, in which early intervention may require subsequent treatments to maintain efficacy over time12.

We therefore suggest that in many interventional settings there exists potential to reduce drug dose much further than has previously been thought possible yet still maintaining efficacy.

The use of prophylactic ofloxacin 200 mg given twice after BCG instillations appears to be a simple and practical method of improving BCG tolerability yet maintaining efficacy.

Research efforts aiming to optimize the delivery of WR-1065 to maintain efficacy while reducing its peak, systemic concentration below levels that induce hypotension are underway.

We hypothesized that controlled release of PHCCC from degradable nanoparticles (NPs) might address these challenges by altering DC function to maintain efficacy with reduced treatment frequency and toxicity.