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A maintained dose intensity is of importance because higher exposures have been shown to be associated with longer OS and time to progression in a previously reported exposure response analysis.
ESA management is also labor intensive and time consuming for health care providers, requiring frequent hemoglobin monitoring to ensure that guideline targets are maintained, dose changes for hemoglobin variation above guideline ranges, and depending on the ESA half-life, administration up to three times a week to maintain appropriate hemoglobin concentrations [ 23].
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At week 24, Group 1 patients crossed over to golimumab 50 mg, Group 2 continued golimumab 50/100 mg per escape status and Group 3 maintained dosing.
To reduce the treatment time and ensure accurate dose delivery to moving targets, the number of intensity levels was minimized while maintaining dose coverage to PTV and minimizing dose to organs at risk (OARs).
To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer.
To reach steady-state levels of the antibody in question an initial dose of twice the maintaining dose was given 4 to 24 hours before wounding.
Growth factors were not allowed to maintain dose intensity.
Growth factor support to maintain dose intensity was administered to 16 patients (73%).
These results confirm the importance of tolerable treatment and maintaining dose intensity.
The prophylactic use of G-CSF to maintain dose intensity was not permitted.
The use of growth factors to maintain dose was not permitted.
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