Sentence examples for maintained cytotoxic function from inspiring English sources

Both groups demonstrated that DKO CAR T cells maintained cytotoxic function in vitro and antitumor function without GVHD in xenograft mouse tumor models.

IL-15 is critical not only in expansion of memory CD8+ T cells in mice but also to maintain cytotoxic T cell effector functions.

MYC inhibitors have been investigated in combination with several chemotherapeutic drugs with the aim of reducing high drug dosage requirements for killing tumor cells, minimizing side effects while maintaining cytotoxic potential.

Namekawa and colleagues [ 54] demonstrated the presence of these cells in the synovial tissue of patients with RA, again postulating that the gain in cytotoxic function is of functional importance in maintaining chronic synovitis.

Our results indicate that viral infection stimulates all major subsets of PBMCs to exert an immediate cytotoxic function.

In the following 2 3 weeks, CD8 T cells contract in number and, while maintaining responsiveness to antigen-specific stimulation, loose cytotoxic function.

Consistent with their more differentiated phenotype, CD4- NKT cells were predominantly resistant to functional reprogramming and displayed higher cytotoxic function.

Activated Tregs might therefore create an environment in which CD8+ T cells are unable to fully exert their cytotoxic functions.

iNOS enzymes produce nitric oxide, critical for cytotoxic function of macrophages.

Varchetta, S. et al. Impaired intrahepatic natural killer cell cytotoxic function in chronic hepatitis C virus infection.

Furthermore, to exploit their cytotoxic function CAR-T lymphocytes need to overcome the limitations imposed by the physical and functional barriers preserving epithelial and mesenchymal compartments.