Sentence examples for maintained cell survival from inspiring English sources

Assessment of Ki67 nuclear proliferation antigen showed that the presence of C4BP maintained cell survival without causing proliferation, inferring that cholangiocytes incubated with sCD154 together with C4BP were held in G0 since Ki67 detects all cells in cycle (figure 1d).

Mechanistically, MEIS1 drives MPNST cell growth via the transcription factor ID1, thereby suppressing expression of the cell cycle inhibitor p27Kip and maintaining cell survival.

The proteasome is involved in degradation of numerous proteins which regulate the cell cycle, indicating a role in controlling cell proliferation and maintaining cell survival.

In hydrogel scaffolds for 3D cell culture, porous structure plays a central role in maintaining cell survival by delivery of biochemical factors through the scaffolds.

The UPR maintains cell survival by limiting cell proliferation and further accumulation of unfolded or misfolded proteins in ER.

In turn trophic factors, such as bFGF, may be needed to maintain cell survival in face of this increased stress.

Nevertheless, it still remains to be clarified how BCR and BAFF-R signals act on one another and are integrated within the cell to maintain cell survival.

For example, EGFR forms a heterodimeric complex with ErbB3, which binds to and directly activates phosphatidylinositol 3-kinase and maintains cell survival through AKT-dependent mechanisms [12].

We have elucidated genes not previously associated with EGFR-mutant NSCLC, two of which enhanced the clonogenicity of these cells, distinguishing these mediators from others previously shown to maintain cell survival.

Whether growth factors are required for durotactic sensing or whether they simply maintain cell survival during durotaxis is uncertain, but it is clear that tension is required for durotaxis [18].

While the mechanism by which CTLA-4 induces anergy is still under investigation [3], [11] [13], it required the PI 3K-PKB/AKT pathway to maintain cell survival under conditions of anergy induction.