Sentence examples for maintained by purifying from inspiring English sources

The loss of such sites indicates that ancestral TIA sites were not maintained by purifying selection.

Tests of selection indicated that integrated genes are maintained by purifying selection.

If these were maintained by purifying selection then U-rich SREs would be uniformly distributed throughout the genome.

Amino acid sequences at SRSs have been likely maintained by purifying selection to retain this regioselectivity even though gene conversion affects the other regions of the gene.

Both molecular evolution and population genetics support the hypothesis that conservation of miRNA binding sites is maintained by purifying selection through elimination of deleterious alleles.

Altogether, our data indicate that SSQ1 was subjected to divergent evolution driven by lowered expression levels and functional diversification, but that critical function was maintained by purifying selection.

Given the CpG → TpG/CpA mutation rate is about one order of magnitude higher than the reverse (Duncan and Miller 1980; Bulmer 1986; Sved and Bird 1990), 1) neutrally evolving codons will move toward a lower frequency of CpG; 2) CpG's at functionally significant codons will be maintained by substantial purifying selection against amino acid changes.

Analysis of human SNP data suggests that these UCRs are maintained by strong purifying selection.

Thus, despite early loss of many genes when heteromorphic Y chromosomes and mtDNA formed, both these nonrecombining chromosomes contain genes maintained by effective purifying selection in the presence of reduced N e.

The present study of within-species nucleotide variation of the L and M opsin genes in gibbons supports the notion that gene conversion has homogenized the tandemly duplicated L and M opsin genes and that their spectral difference is maintained by the purifying selection on the centrally-located exons in non-human catarrhines.

Episodic diversifying selection could have affected Tlr4 throughout its evolution and this process could still be in operating, while in Tlr7 diversifying selection seemed to have appeared more recently and the gene history was mostly maintained by the stronger purifying selection.