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Heterozygous mice were maintained by crossing to C57Bl/6 mice.

The colony was maintained by crossing mdx males with mdx females.

The colony was maintained by crossing mdx∶utrophin+/− males with mdx∶utrophin+/− females.

The transgenic lines were maintained by crossing founders (F0) and F1 homozygous mice with wild type BDF1 partners.

The GarsC201R/+ parents used in this cross were as described above i.e. maintained by crossing to C57BL/6 but not congenic.

The cre (and thus BALB/cJ) -ve Dnmt3L colony has been maintained by crossing heterozygotes or crossing to wildtype C57BL/6 for well over 10 generations.

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Although Danny Briggs bowled Brown and Simon Katich with successive balls in the 12th over, the momentum was maintained by Cross and Steven Croft with 68 off 35 balls for the fifth wicket.

Transgenic lines were maintained by cross breeding for more than four generations with the genetic background of Wistar rats.

The RAP knockout mice were congenic on the C57BL/6J background while the parental APPswe/PS1dE9 mice were hybrids of C57BL/6J and C3H/HeJ (maintained by crosses of transgenic males to F1 hybrids of the 2 strains purchased from Jackson Laboratory).

Moreover, heterogeneity within GBM is maintained by cross-talk between genetically distinct tumor cell SPs (Inda et al., 2010).

In some cases the domains were maintained by cross-regulatory interactions (sea urchins, for instance), although this could also be maintained even in the event of cluster disintegration.

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