Heterozygous mice were maintained by crossing to C57Bl/6 mice.
The colony was maintained by crossing mdx males with mdx females.
The colony was maintained by crossing mdx∶utrophin+/− males with mdx∶utrophin+/− females.
The transgenic lines were maintained by crossing founders (F0) and F1 homozygous mice with wild type BDF1 partners.
The GarsC201R/+ parents used in this cross were as described above i.e. maintained by crossing to C57BL/6 but not congenic.
The cre (and thus BALB/cJ) -ve Dnmt3L colony has been maintained by crossing heterozygotes or crossing to wildtype C57BL/6 for well over 10 generations.
The SOD1G93A parents for the cross described came from a colony in which the transgene array is maintained by crossing SOD1G93A hemizygous males to wildtype F1 SJL x C57BL/6) females, as recommended by the Jackson Laboratory (hemizygous SOD1G93A females are infertile).
The RAP knockout mice were congenic on the C57BL/6J background while the parental APPswe/PS1dE9 mice were hybrids of C57BL/6J and C3H/HeJ (maintained by crosses of transgenic males to F1 hybrids of the 2 strains purchased from Jackson Laboratory).
The background strain of mice used for many studies of the human SOD1 mutation is a B6SJL mixed hybrid strain [B6SJL-TgN SOD1-G93A 1GUR] maintained by crossing transgene-positive male mice with B6SJL F1 hybrid females.
