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To ensure immune tolerance, regulatory T cell (Treg) numbers must be maintained by cell division.
Compartments were originally described in Drosophila imaginal discs as subdivisions of organ primordia occurring on an homogeneous epithelial cell field and whose coherence is maintained by cell lineage [1] [3].
In unicellular organisms, uniform cell sizes are maintained by cell size checkpoints [ 19, 33].
The senescence was instigated by low level of persistent DNA damage maintained by cell exposure to DNA-targeting drugs mitoxantrone [ 39] or mitomycin C [ 40].
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A pioneer in epigenetics, a field that encompasses the study of non-DNA sequence related heredity, Feinberg studies how such information is maintained by cells through cell divisions and generations.
Thus, we wondered whether the metastatic phenotype of the metastasis-derived K5L cells was maintained by cells propagated in culture.
This significant overrepresentation we interpret as a consequence of biological importance of autoregulatory network motifs in regulation of processes maintained by cells.
Augmented cell adhesion was maintained by cells transfected with point mutated, inactive heparanase, or in the presence of laminaran sulfate, an inhibitor of heparanase enzymatic activity [27], arguing for enzymatic-independent function.
This property is maintained by cells of more differentiated mesenchymal lineages, such as fibroblasts.
Previous reports by us (1, 6) and others (11– 14) demonstrate that long-term hematopoiesis in dUCBT recipients is maintained by cells derived from a single UCB unit.
Double umbilical cord blood transplantation (dUCBT), developed as a strategy to treat larger patients with hematologic malignancies, frequently leads to the long-term establishment of a new hematopoietic system maintained by cells derived from a single UCB unit.
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