Exact(2)
We maintained allocation concealment until after we obtained written consent and completed baseline measures.
A summary of the validity assessment for the 17 RCTs is displayed in Table 2. Most studies had balanced groups at baseline and performed their analysis on an intention-to-treat basis; however, only two RCTs used methods to blind the adjudication of outcomes while only seven RCTs clearly maintained allocation concealment.
Similar(57)
Central randomisation by an independent allocator maintains allocation concealment.
Our approach uses software analysis to eliminate the need for maintaining allocation and free records.
In 1995, a 90-day credit was given to patients with idiopathic pulmonary fibrosis, while still maintaining allocation based on waiting list time.
Randomizations occurred from 11 January 2001 to 29 October 2005 using permuted blocks to maintain allocation concealment.
Studies that used a method of randomization that did not maintain allocation concealment, such as alternate days or medical record numbers (that is to say. were pseudo-randomized) were recorded as not maintaining allocation concealment.
In contrast, study design to maintain allocation concealment was conducted or reported in less than half of the reviewed RCTs.
To maintain allocation concealment, randomisation is performed in real time by a web interface (Filemaker Server Advanced, Filemaker Inc, Santa Clara, California, USA).
Study personnel will be unaware of treatment allocation prior to the assignment of interventions, using sequentially numbered, opaque, sealed envelopes to maintain allocation concealment.
Therefore, the presence of methods to maintain allocation concealment was the only study quality factor used to assess for influence on the pooled effect estimate.
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