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Another three cases without any related clinical signs, 2 females and one male aged 41, 64, 47 respectively, maintained abnormal liver functional indices after six months and also fulfilled the diagnostic criteria of PBC proposed by EASL.
Since the evaluation of behaviour and its consequences is necessary to determine whether or not current strategies should be maintained, abnormal response monitoring may contribute to behavioural rigidity in ASD.
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Neuropathic pain is due to lesion or dysfunction of the peripheral or central nervous system, which generates and maintains abnormal, increased neuronal sensitivity [1].
In cancer cells, VEGFA induction mediated by the UPR is used to maintain abnormal ER homeostasis and help these cells to survive and proliferate under chronic ER stress conditions caused by nutrient deprivation and hypoxia.
Accumulating evidence suggests that dorsal horn glia cells might have an important role in producing and maintaining abnormal pain sensitivity [ 54, 55].
When grown in osmotically stabilizing media, these pck2Δ cells after protoplast recovery (which we will refer to as " RP-pck2Δ cells") epigenetically maintain abnormal morphology for many generations.
Cancer cells may be distinctive in that DNMT1 alone is not responsible for maintaining abnormal gene-specific hypermethylation, and both DNMTs 1 and 3b may cooperate in this action (Rhee et al. 2000, 2002).
Other groups have suggested that in fact a small proportion of virally infected cells persist and secrete paracrine growth factors that maintain abnormal growth of a larger majority of uninfected cancer cells.
Results indicated vital role of glutathione in maintaining abnormal proliferations in plant organs, and its deficiency triggered phenotypic reversal through metabolic diversions of cysteine and concomitant cellular and metabolic modulations.
Next, we investigated whether the characteristics of CSLCs in tumorspheres were maintained by abnormal activation of the SHH pathway.
In order to confirm that the cells isolated from the primary tumour maintained an abnormal genotype in culture, we carried out FISH on a subset (n=5) using probes for six chromosomes and compared this with normal cells purified from reduction mammoplasty specimens (n=5).
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