Sentence examples for maintained a high affinity from inspiring English sources

Furthermore, it was found, that the 3-isoquinolinyl fragment was less preferable than 7-quinolinyl for interaction with D2Rs (4 vs 5) and shortening of the alkylene linker (from 4 to 3 methylene units) maintained a high affinity for D2Rs (4 vs 6).

These mAbs maintain a high affinity and tight interaction with their antigen during loading and washing, but release under special gentle conditions.

At the starting point of AncSR1 ERE, both the TF and the RE genotypes are highly constrained by the requirement to maintain a high-affinity complex with each other: only a single mutation is available to the DNA (from GT to GG), and only one replacement (glu25GLY) is available to the protein.

Like any FA-drug conjugate, the first step in the EC0746 screening process was to make sure that it maintains a high binding affinity towards the cell-surface FR to allow for efficient uptake via endocytosis.

Binding studies revealed that our peptide, Synb1-ELP-TRTK, interacts with its molecular target S100B and maintains a high S100B binding affinity as comparable with the TRTK12 peptide alone.

This protein maintains a high, albeit attenuated, affinity for ssDNA (Bell, 2011; Bell et al., 2012).

Indeed, HERV expression was detected in the thymus, where immune tolerance toward self is maintained via central tolerance; thymocytes with a high affinity for self-antigens are deleted, thus the remaining thymocytes (the future CD4+/CD8+ T cells) are likely to have a low affinity for HERV-like antigens.

This could be explained by the action of lipid emulsion as a high affinity conduit - maintaining blood concentrations able to interact with the brain during early redistribution to hydrophilic tissues, before augmenting later redistribution from rapidly perfused to lesser perfused lipophilic tissues [ 41].

As a result of lecithinization, PC-SOD exerts a high affinity for cell and tissue membranes, maintaining prolonged pharmacological activities in vivo, and ameliorated fibrosis in bleomycin-induced pneumonitis in mice [ 10].

Ku also binds to telomeres via a high affinity interaction with TRF1, a component of the telomere shelterin complex and has a role in maintaining the stability of telomeres [18].

On the other hand, newer sulfonylureas glimepiride and glicazide have a high affinity for SUR1, the pancreatic receptor, but low affinity for cardiac SUR2A or vascular SUR2B and, therefore, are able to maintain IPC (15– 15).