This was first derived from the study by Rivers and colleagues, in which most EGDT-treated patients had received RBC transfusion to maintain a hematocrit level above 30% [5].
In addition, the widely circulated recommendations of the Surviving Sepsis Campaign regarding blood transfusion in patients with septic shock include a recommendation for transfusion to maintain a hematocrit of more than 30%% in the presence of hypoperfusion in the first 6 h [41].
Response was durable; among responding patients, the probability of maintaining a hematocrit < 45% without phlebotomy for 48 weeks and 144 weeks, respectively, was 85% and 61% (Fig. 1c).
During and after CPB, additional RBCs were administered as needed in order to maintain a hematocrit value within our standard range.
Packed red blood cells (200 to 500 mL) were transfused as necessary to maintain a hematocrit level above 30% during CPB [ 26].
In addition, the widely circulated recommendations of the Surviving Sepsis Campaign regarding blood transfusion in patients with septic shock include a recommendation for transfusion to maintain a hematocrit of more than 30%% in the presence of hypoperfusion in the first 6 h [ 41].
After each patient was separated from CPB, RBCs were transfused to maintain a hematocrit level above 24% in cases of abnormal bleeding or to increase oxygen delivery in cases of persistent lactic acidosis after optimization of cardiac output with inotropes, vasoactive agents or both.
In contrast, mutant mice maintained a low hematocrit for at least two more days and 25% of them died at day 4 or 5.
Clinical symptoms are effectively relieved by phlebotomy, but the increased risk of cardiovascular morbidity is not ameliorated by maintaining a normal hematocrit [30].
Fresh human red blood cells were obtained from Dutch National blood bank (Sanquin Nijmegen, NL; permission granted from donors for the use of blood products for malaria research), washed in serum free medium, and these were added to these cultures at parasitemias between 2 7%, thereby reducing the parasiteamia to 0.5% while maintaining a 5% hematocrit.
