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Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak.
This review will consider how the identification of the genetic factors contributing to different vascular malformations, with subsequent functional studies in animal models, has provided a better understanding of these factors that maintain vascular integrity in vascular beds, as well as their role in the pathogenesis of vascular malformations.
For example, pVHL has been shown to bind and stabilize microtubule structures [18], and regulate fibronectin deposition to maintain vascular integrity [19], [20].
However, despite enhanced initial colonization in the lung, the later requirement for CD34 to maintain vascular integrity and promote tumor growth is dominant and CD34 ablation results in fewer detectable metastases at the day 12 time-point (Figure 1B).
VEGF stimulates endothelial cell proliferation and promotes endothelial cell survival, thereby helping to maintain vascular integrity.
Thus, MMP9 expression must be kept in check to maintain vascular integrity.
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The vascular endothelial structure forms a barrier that maintains vascular integrity so that blood components circulate only inside the vasculature.
The angiopoietin/TIE2 (ANG/TIE2) pathway maintains vascular integrity, and negative regulators of this pathway are potential therapeutic targets for these diseases.
We here demonstrate that VASP is crucial for maintaining vascular integrity in the ischemic brain.
Our studies reveal a complex role for polycystins in maintaining vascular integrity.
These pathways exert important vascular actions, such as maintaining vascular integrity, regulating cell cycle, and promoting vasculogenesis.
More suggestions(15)
maintain vascular quiescence
maintain academic integrity
maintain vascular supply
maintain vascular leakage
maintain vascular structure
maintain vascular health
maintain synaptic integrity
maintain chromosomal integrity
maintain vascular homeostasis
maintain vascular state
maintain genome integrity
maintain vascular morphogenesis
maintain structural integrity
maintain vascular barrier
maintain vascular function
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