Heat shock protein 90 (Hsp90) is an important target in cancer because of its role in maintaining transformation and has recently become the focus of several drug discovery and development efforts.
The results also showed that deliveries tended significantly to maintain the transformation zone on the exocervix.
No specific/effective pharmacological treatments exist; thus, immunotherapy can be a valid option, particularly because the HPV lesion/cancer possesses strong tumour-associated antigens (TAA) represented by the major oncoproteins E6/E7 always expressed and necessary to maintain the transformation status.
A set of genes seems to remain regulated by v-Src during SSeCKS re-expression, suggesting that their expression levels are not sufficient to induce or maintain oncogenic transformation in the presence of physiologic levels of SSeCKS.
The atmosphere built throughout, there were dangerous challenges worthy of a derby and Scotland maintained their transformation under Gordon Strachan with a worthy winner from Shaun Maloney's well-rehearsed, supremely executed corner kick routine.
One key area where the team may appear different is in central midfield where it will be fascinating, and perhaps decisive, to see if Yaya Toure maintains his transformation from a holding player into a box-to-box goalscoring midfielder.
Multiparity may increase the risk of CC by maintaining the transformation zone on the ectocervical region.
Although hTERT is not oncogenic per se, the activation of hTERT is essential for maintaining neoplastic transformation [ 66].
This increased GLUT3 expression in macrophages is maintained after transformation to foam cells and is thought to provide fuel for the immune response, in addition to allowing leukocytes to compete for sugars in low-interstitial glucose concentrations [Fu et al., 2004; Maratou et al., 2007].
In contrast with other guidance methods, which communicate the target position numerically, using optical commands avoids the need to maintain the coordinate transformation between the robot's system and that of the environmental model ("world" reference coordinates).
