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Regulatory T (Treg) cells establish and maintain tolerance to self-antigens and many foreign antigens, such as allergens, by suppressing effector T-cell proliferation and function.
Natural thymic T regulatory (tTreg) cells maintain tolerance to self-antigen.
Failure to maintain tolerance to self-antigens or innocuous antigen results in the development of autoimmune or allergic disease, respectively.
In contrast, c-FLIPL transgenic (Tg) mice in the C57BL/6 (backgroundound maintain tolerance to nuclear antigens, and are resistant to the development of lupus-like disease.
Acute cellular rejection (ACR) involves the interplay between mechanisms that maintain tolerance to the graft and factors that promote rejection [ 22].
NKT cells, which are potent producers of cytokines, foster protective immunity to microbes and tumor cells, but also help maintain tolerance to self.
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Communication between different immune cells of the intestinal mucosa acts as a rheostat that maintains tolerance to gut microbes.
The main function of DCs is to induce T-cell activation, polarization and expansion against invading pathogens while maintaining tolerance to self antigens (Steinman, 2007).
By maintaining tolerance to opioids, such maintenance medications could also cut the death rate by 50percentt or more.
Naturally occurring CD4+CD25highFoxp3+ regulatory T cells (nTreg) are essential for maintaining tolerance to self and regulating immune responses to foreign antigens.
Thus, HPC-derived cells persisted in the bone marrow, possibly maintaining tolerance to the graft by supplying donor cells into the blood circulation.
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