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Biomaterials are emerging as extracellular-mimicking platforms designed to provide instructive cues to control cell behavior and ultimately, be applied as therapies to repair, improve, or maintain tissue function.
Throughout our life span, cells have to be repaired or regenerated in order to maintain tissue function.
This would prevent precancerous cells from proliferating continuously, but might give normal cells a temporary boost to maintain tissue function for a few more years.
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Such degeneration-regeneration cycles rejuvenate the tissue and help maintain tissue functions [ 1].
The superficial zone (SZ) of articular cartilage is critical in maintaining tissue function and homeostasis and represents the site of the earliest changes in osteoarthritis (OA).
However, the role of TRF2 in later stages of development and in the adult organism remains largely unaddressed, with the exception of liver, where TRF2 was found to be dispensable for maintaining tissue function.
Consistent with the importance of mitochondrial maintenance in aging, certain interventions that increase mitochondrial proliferation, such as over-expression of PGC1alpha in gut tissue, have recently been reported to increase life span and tissue function in aging Drosophila [ 49, 50], and PGC1alpha activity is also implicated in maintaining tissue function during aging in mammals [ 51].
This indicates that N-cad provides the essential features to maintain tissue architecture and function which implies fully overlapping function of E- and N-cadherin in the alveoli.
The HNF4α-dependent transcription of HNF1α is required for normal β-cell function [16], but there is also a feedback loop of HNF4α and HNF1α to maintain tissue specific metabolic function [16] [18].
To identify genes and pathways that maintain tissue structure and function in old age, new approaches for quantifying tissue morphology are needed.
What is not understood is how a slight increase in temperature (20°C to 25°C, which is not typically thought of as a stressful environment for C. elegans) or a change in equally accepted laboratory food sources influence an animal's ability to maintain tissue structure and/or function (an unimpaired versus an impaired phenotype) after anoxia treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com