Sentence examples for maintain their suppressive from inspiring English sources

However, it is not clear from these studies how long these induced Tregs needed to maintain their suppressive phenotype to alter the disease course.

We restimulated ATRA-expanded Tregs with anti-CD3 Ab-loaded K.64.86 cells to determine whether ATRA-expanded Tregs could also maintain their suppressive phenotype after an additional round of expansion in the presence of ATRA.

Our findings are of particular interest, as c-Rel is crucial for the induction of Foxp3 in regulatory T cells during thymic development, but has to be repressed in mature regulatory T cells to maintain their suppressive phenotype.

However, these cells maintain their suppressive function.

Therefore, we reprogrammed these cells by ectopic expression of Foxp3 to maintain their suppressive activity.

However, when functional assays were repeated on frozen PBMCs, the same cells failed to maintain their suppressive activity.

CD8+ T-cells maintained their suppressive activity for >100 days following DST treatment alone (Fig. 3B).

rhIGF-1 administration increased Treg cells in affected tissues, maintaining their suppressive properties.

In addition to enhancing their survival, the γc cytokines also maintain CD25 and Foxp3 expression in Treg cells, thus maintaining their suppressive potential.

Tfr cells are a subset of Foxp3+ Treg cells that adopt features of Tfh cells to enable them to migrate into the GC while maintaining their suppressive function.

Opposed to a previous key publication [ 32], we find that at baseline these cells are functionally as suppressive and have similar phenotypic/molecular characteristics to subpopulations I and II of Treg cells, but that they have the potential to produce IL-17 while maintaining their suppressive function.