Sentence examples for maintain their efficacy from inspiring English sources
Understanding the mechanisms behind benzodiazepine tolerance is critical for designing drugs that could maintain their efficacy during long-term treatments.
The results we report demonstrate that the impact of sarA on biofilm formation is epistatic to agr, and this implies that, irrespective of the specific mechanism involved, such inhibitors would maintain their efficacy even in the context of the accumulation of agr mutants that occurs not only within biofilms [6] but also in vivo during the course of antimicrobial therapy [15].
However, there is still a gap in the knowledge about how to use OCs and how to maintain their efficacy.
To maintain their efficacy, other strategies using the intermittent application of different features need to be employed within concerted health campaigns.
Since the potency of competitive inhibitors is reduced as the concentration of substrate rises, allosteric noncompetitive or uncompetitive inhibitors that bind in the presence of substrates and maintain their efficacy have many advantages.
Although such strategies might well be implemented and tightly controlled in closed health care systems such as intensive care units, the challenge now is to maintain their efficacy in a less restrictive system and for a wider array of prescribers.
The variety of antiparasitics that can be used against caligid copepods is limited and efforts are needed to maintain their efficacies.
Blocking/neutralizing antibodies anti-PD-1 IgG nivolumab (Fig. 1B), anti-VEGF IgG bevacizumab (Fig. 1C), and anti-TNFα IgG infliximab are among largest selling pharmaceuticals that could maintain their efficacies in an aglycosylated format as demonstrated by the licensed therapeutic Fab fragments certolizumab and ranibizumab specific for TNFα and VEGF-A, respectively.
Based on current experimental findings these Ti-TNTs wire implants have shown promising capacity to load and deliver anti-cancer agents maintaining their efficacy for cancer treatment.
Before translating these results on clinical trials, we further checked if these therapies maintained their efficacy in "febrile" conditions.
Five compounds passed the initial high-concentration screening and all of them failed in maintaining their efficacy at nanomolar concentrations.
