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Bacterial translocation from the gut has been suggested to induce and maintain the systemic inflammatory response (SIRS) and organ dysfunction.
However since local wounds initiate and maintain the systemic disorders and provoke the aesthetic and functional sequellae, its significance must be stressed.
Biphasic drug release profiles have drawn considerable attention in pharmaceutics for a number of reasons - one possible application is the 'burst' release of a loading dose of drug followed by sustained release over a prolonged period of time to maintain the systemic drug concentration within the therapeutic window [21 23].
When a normal individual stands up from a lying position, the baroregulatory reflex produces vagal inhibition and sympathetic stimulation, resulting in an increase in heart rate and vasoconstriction to maintain the systemic blood pressure.
In particular, the pleiotropic pro-inflammatory cytokine interleukin-6 (IL-6), upregulated by tissue injury/necrosis and inflammatory cells such as macrophages, has the ability to activate and maintain the systemic inflammatory response through trans-signalling pathways involving the soluble IL-6 receptor (Guthrie et al, 2012).
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A continuous infusion of calcium gluconate 10%% at the outflow port of the catheter maintained the systemic ionized calcium.
The secretion of SASP-related cytokines may be necessary for maintaining the systemic inflammatory response within the placenta and promote a continuous interaction with the immune system.
GL could maintain the stability of systemic hemodynamics, improve pulmonary oxygen exchange and metabolic status in porcine endotoxemia.
The main findings of this study were that, following LPS treatment: 1) GL could better maintain the stability of systemic hemodynamics and improve pulmonary oxygen exchange and metabolic status.
The lawsuit, prepared by lawyers representing seven tenants, accused the agency of a "widespread and systemic failure to maintain the elevators in its buildings in operable working condition," in violation of disability and human rights laws.
In summary, neither vertical nor systemic transmission alone can maintain the pathogen, but cofeeding transmission can.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com