Sentence examples for maintain the specificity from inspiring English sources

Some of the key questions in understanding the ecology and evolution of mutualisms are what factors maintain the specificity and stability of mutualist pairings (e.g., [4] [7]).

Humanization via variable domain resurfacing is another approach that can maintain the specificity and binding affinity of parental antibody, which can reduce the immunogenicity of antibodies through the replacement of surface exposed residues in the murine FRs with those usually found in human antibodies [11], [12], [13], [14], [15].

Given that the murine mAb 18B7 has undergone clinical testing and that has been extensively studied in the laboratory, one approach was to generate chAbs as potential therapeutic reagents, with the assumption that expression of mAb 18B7 V regions in combination with human C regions would maintain the specificity and affinity of the murine mAb.

In order to maintain the specificity of the diverse hormone responses, cAMP signaling is compartmentalized [ 43, 49].

This is hardly surprising since the bacterial systems were required for thylakoids and therefore a new transport machinery had to be developed in the host cell to maintain the specificity for chloroplast communication.

In our hands, use of the new EO criteria for diagnosis of CM increases the sensitivity and maintains the specificity of decision making, and therefore should be adopted in CM management practice.

Thus, the Hpx domain in the C-terminal region maintains the specificity of collagenase family MMPs by affecting the substrate binding [2].

An ideal antibody humanization should be capable of maintaining the specificity and affinity toward the antigen and reduces the immunogenicity as much as possible.

Although the generalizability of the observations with mAb 18b7 and chAb 18B7 to other chimeric Abs is unknown, our findings suggest caution with assuming that simply replacing the C region domain maintains the specificity and affinity of the V region.

This mechanism could participate to maintaining the specificity of olfactory communication in a noisy environment, e.g. when males have to detect minute amounts of sex pheromone in a high background of various plant volatiles.

The scFv maintains the specificity of the original antibody, but carries the advantage of small size suitable for expression as part of a CIR.