Sentence examples for maintain the silenced from inspiring English sources

We conclude that nuclear small RNA factors are required to maintain the silenced state over many generations, whereas the piRNA trigger that initiates silencing becomes dispensable if the silent locus is outcrossed multiple times.

Thus, multiple epigenetic layers act together to maintain the silenced state of the Xi and Xist retains some role in gene silencing in the maintenance phase that is appreciated only when other repressive modifications are inhibited.

Prior reports have indicated that it may be difficult to maintain the silenced state of regions of just a few nucleosomes in length; hence, we suspected that RNAP V may be responsible for the silencing of small repetitive regions.

The other ICM cells that are expressing GATA4/GATA6 will maintain the silenced paternal X and differentiate into PrE.

Surprisingly, we found all the genes, except for AGO1, are required to maintain the silenced state of LUC'.

By utilizing the available mutants in the Col ecotype that affect DNA methylation and/or histone modifications, we next determined which epigenetic marks are required to maintain the silenced state of LUC'.

And Schatten himself continues to maintain the silence he has held ever since he broke off his collaboration with Hwang last November.

There, in the cool earth, surrounded by dark bones, my grandmother bore her first child, whose mouth was quickly filled with a fragrant nipple to maintain the silence that was essential: Death had a thousand ears!

Rather, postmeiotic repression will maintain the silencing at the same level, or genes will be released from silencing.

They maintain the silencing or low expression of many genes in ESCs, which are poised for activation in differentiated cell types [ 33, 63].

Gudkov and co-workers recently reported (also on line first) that p53, a tumor suppressor protein, recently renamed TP53, cooperated with DNA methylation to maintain the silencing of a large portion of the mouse genome.