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Thus, these diverse consortia must possess "functional equivalence" which allows the whole to establish and maintain the chronic infection.
Furthermore, this response was able to sterilize the lesion, whereas the non-immune model was only able to maintain the chronic infection.
Thus, we suggested that parasites induce immune responses that control the infection and also lead to tissue injury creating a microenvironment that maintain the chronic inflammation.
For instance, increased blood vessel formation, and hence an increased surface area of vessels, can maintain the chronic inflammatory state through increased production of cytokines and by allowing inflammatory cells to access the inflamed synovial tissue.
Abnormal brain processing includes sensitization supported by aberrant inter-regional communication and other alterations in both structure and function, including neurotransmitter levels, all of which may ultimately maintain the chronic pain state.
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Together, pro-inflammatory responses may be responsible for maintaining the chronic status of chronic wounds.
H MGB1 could play a role in maintaining the chronic inflammation.
Granuloma macrophages are also responsible for maintaining the chronic inflammatory response.
Recent data implicate the hypoxia status, maintaining the chronic inflammation in tumor, also contribute to MSCs mobilization [ 110].
But Zivari and other experts still maintain that the chronic dissatisfaction experienced by many couples might have been relieved if they had sought professional help early on.
Nevertheless, as this review consistently reminds us, there are still very large gaps in our knowledge of what is occurring in the nociceptors to maintain this chronic pain state.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com