Exact(4)
In most cases, GERD is considered a chronic disorder requiring long-term acid suppression to maintain symptomatic remission and/or healing of erosive esophagitis [ 1, 2].
Taken together, these LD-controlled trials of DA monotherapy in early PD clearly show the need for LD supplementation to maintain symptomatic control.
At four years' follow-up in the CALM-PD trial, 72% of patients randomized to pramipexole monotherapy had required add-on LD to maintain symptomatic control, and this figure was 66% after five years in the 056 study with ropinirole.
Indeed, PD patients initiated on a DA in these trials eventually required supplemental LD in order to maintain symptomatic control, and developed dyskinesias at an identical rate (albeit with a delay) to those started on LD, leading to steady increases in dyskinesia rates from this point onwards.
Similar(56)
The primary efficacy endpoint was the number of patients who maintained symptomatic remission for 3 months, as determined by mPDAI symptom scores.
This historical cohort open-label study investigated the efficacy and tolerability of rifaximin in maintaining symptomatic and endoscopic remission in patients with antibiotic-dependent pouchitis.
In the long-term study, with open-label, dose-optimized LDX treatment, most adults with ADHD achieved clinical response and/or symptomatic remission; almost two-thirds maintained symptomatic remission over the remaining 11 months.
Individuals who are able to adhere to exercise almost always maintain the symptomatic benefits of exercise.
MPH-LA provided and maintained significant symptomatic and functional improvement in adult ADHD patients.
Blinding was maintained until symptomatic deterioration, study-agent crossover, or serious unexpected adverse reaction.
Over a two-decade period, 31/44 patients required only one WLL to maintain long term symptomatic control, with 13/44 requiring multiple WLLs.
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