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In adults, it remains crucial to maintain stem cells.
Of key importance are the transcription factors Oct-4 (octamer 4) and Sox-2 (sex-determining region Y box 2), which maintain stem cells in a primitive state.
The ability to maintain stem cells in tissues is a key factor in regenerative medicine or organ transplantation, as an abundant supply of healthy stem cells must be available for damaged tissues.
Plants maintain stem cells in their meristems as a source for new undifferentiated cells throughout their life.
The physiological hypoxia of the early gestational sac protects the developing fetus against the deleterious and teratogenic effects of oxygen free radicals but it is also necessary to maintain stem cells in a fully pluripotent state [4] for at physiological levels free radicals regulate a wide variety of molecules, in particular transcription factors [5].
Pumilio mutant Drosophila not only failed to maintain stem cells but germline cells also.
Similar(41)
They undertook the present study to determine how Id proteins maintain stem cell identity.
Wilms cells also express "embryonic" chromatin regulators and maintain stem cell-like p16 silencing.
A few key growth factors, such as WNT, Noggin, R-spondin and EGF, were supplemented mostly to maintain stem cell populations.
TCF21 expression allows fetal Leydig cells to maintain stem cell like characteristics.
Interestingly, haemopoiesis also utilizes Notch signalling to maintain stem cell identity and to diversify cell types during lineage elaboration [50].
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