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They undertook the present study to determine how Id proteins maintain stem cell identity.
A few key growth factors, such as WNT, Noggin, R-spondin and EGF, were supplemented mostly to maintain stem cell populations.
Ever since Schofield coined the term "niche" in 1978, great strides have been made to discover molecular signals and cellular support systems that maintain stem cell functionality in flies, worms, and mammals.
TCF21 expression allows fetal Leydig cells to maintain stem cell like characteristics.
Interestingly, haemopoiesis also utilizes Notch signalling to maintain stem cell identity and to diversify cell types during lineage elaboration [50].
In addition, the conditions under which the cells are expanded in vitro must maintain stem cell characteristics.
Indeed, some studies have indicated that microgravity suppresses cellular differentiation thereby providing a potentially effective means to maintain stem cell characteristics.
FE-Pro labeled NSCs retain their proliferative status, tumor tropism, and maintain stem cell character, while allowing in vivo cellular MRI tracking at 7 Tesla, to monitor their real-time migration and distribution at brain tumor sites.
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Wilms cells also express "embryonic" chromatin regulators and maintain stem cell-like p16 silencing.
Thus, in agreement with those in previous reports, our results indicated that c-Met is a good marker for pancreatic CSC and functions to maintain stem cell-like phenotypes.
Wg/Wnt signals specify cell fates in both invertebrate and vertebrate embryos and maintain stem-cell populations in many adult tissues.
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