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Pre-treatment of BMSC with U0126 and SB 203580 in concentrations held low enough to maintain specificity of inhibition resulted in approximately a 50% decrease of IL-6 upon exposure to NGF or BDNF (Figure 7).
Thus, restriction of lateral diffusion by endocytosis may serve to maintain specificity of syntaxin localization during late cytokinesis.
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In addition, Scambler et al. [ 87] described how a slight change in CHAT criteria to allow parents to endorse either of two critical items, improved CHAT sensitivity by 20%% while maintaining specificity of 100%% in a group of children with developmental disabilities.
This important difference allows selection of ligands that maintain specificity for cancer cells by preventing nonselective membrane penetration.
On VFA, AAC-8 and 24-point scale cutpoints, respectively, of ≥3 and ≥5 had the best sensitivity while maintaining specificities of 95% or higher.
These binding sites maintain specificity by means of their sequence, and other additional factors such as inter-motif distance and spacer specificity.
The low (biological) plausibility of opposite change scores within the patient and the lack of opposite results by other reader(s) protect the scoring system against a lack of sensitivity while there is a natural tendency to maintain specificity (conservatism in case of doubt).
The 3.5 score threshold was used to maintain specificity, although at the cost of sensitivity, in the target prediction algorithm.
Such complexity is likely key to maintaining specificity given the multitude of stimuli which use calcium to mediate their physiological effects.
In order to maintain the specificity of the diverse hormone responses, cAMP signaling is compartmentalized [ 43, 49].
Saeed, despite the incitements of his subject, does not aspire to the Kafkaesque — Kafka, it must be admitted, is among the most impossible of authors to emulate, along with García Márquez — but maintains a specificity of place and history (this happened in Basra, that happened in Mosul) and of the individuals who inhabit them.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com