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Our data, obtained from two distinct mouse models suggest that the ECD of Lrp1b can function to some extent to maintain signaling homeostasis even in the absence of membrane integration.
Potentially, the residual flotillin-1 expression was sufficient to maintain signaling.
Whether the Gap1, Mep2, or Pho84 transceptors are able to maintain signaling to the PKA pathway, once internalized, is unknown.
These molecular associations suggest that tumors can arise from different cell populations and maintain signaling networks of their cell of origin.
This work sets the stage to identify molecular mechanisms that cutaneous afferents use to maintain signaling fidelity during normal tissue remodeling and in the context of repair.
The delayed endocytosis of SPE-7-bound FcεRI, therefore, may maintain signaling at the membrane for the extended times needed to promote mast cell survival.
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Patterson JC, Klimenko ES, Thorner J (2010) Single-cell analysis reveals that insulation maintains signaling specificity between two yeast MAPK pathways with common components.
In contrast, Gremlin, a BMP-dependent antagonist of BMP signaling essential for maintaining signaling pathways regulating limb patterning, is expressed in central mesenchyme (Figure 4F) [21] [25].
We find that a large iSAT at the ON state maintains signaling sensitivity while minimizing noise propagation.
In this study, we analyzed the fitness consequences of maintaining signaling elements that mediate early herbivory-induced defense responses in native tobacco, Nicotiana attenuata.
Furthermore, a Y8H polymorphism that maintains signaling and antiviral activity in transient assays has been detected in humans (Sauter et al., 2013).
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