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Mesalazine is widely used systemically or topically to achieve and maintain remission in inflammatory bowel disease.
Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease.
Azathioprine or methotrexate are also used as the sole therapy to maintain remission in these diseases, and their dose is optimized based on the weight of the patient.
Gerss, J. et al. Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study.
In addition to dietary approaches, there are a number of drugs that can be used to induce and/or maintain remission in CD [12].
The cumulative incidence of relapse at 2 years was 44%9595% CI, 35%to53%3%).Reduced-intensity conditioning HSCT to maintain remission in selected older patients with AML is relatively well tolerated and appears to provide superior outcomes when compared with historical patients treated without HSCT.
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Chloroquine is used both for therapy and to maintain remissions in SLE patients.
Although vigorous immunosuppressive treatments induce and maintain remissions in a majority of patients, they carry an increased risk of serious complications.
The prodrug azathioprine is primarily used for maintaining remission in inflammatory bowel disease, but approximately 30% of the patients suffer adverse side effects.
The ability of maintaining remission in UC patients by a daily supply of 10 g of Plantago ovata seeds (also called psyllium or Ispaghula husk) was compared with daily treatment with 500 mg of mesalamine and a combination of the two [26] Twelve months of treatment failed to demonstrate any difference in clinical benefits between the three groups.
These data also suggest that there is a self-renewing PR1-CTL population that may contribute to maintaining remission in this subset of patients.
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