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Certain interactions recruit and maintain proteins in the apical domain.
An enhanced capacity for oxidized BiP to bind polypeptides may serve to maintain proteins in a folding-competent state until the ER returns to a more reduced status.
This finding suggests that it is important to maintain proteins in their functional conformations and prevent the aggregation of nonnative proteins under stress.
In fact, cultivation of Δ trr1 deletion mutants without the potential generation of suppressors was only possible when the medium was supplemented with cysteine, presumably to maintain proteins in their reduced state.
Similar(56)
Therefore, Prx6 may play a major role in maintaining proteins in a reduced state by scavenging toxic ROS.
The presence of a nuclear localization sequence is a prerequisite for maintaining proteins in the nucleus, whereas a nuclear export sequence maintains proteins in the cytosol.
Stability is essential for maintaining proteins in their native state, in a precise confirmation needed for the function of that protein.
Acting as molecular chaperones, HSPs can play an important role in maintaining proteins in a folded or unfolded state, controlling the unintended aggregation of proteins or target proteins for degradation [ 86].
Abiotic stresses usually causes protein dysfunction; so maintaining proteins in their functional configurations and preventing the aggregation of non-native proteins is particularly important for cell survival under stress [ 14].
Thioredoxin is the major ubiquitous disulfide reductase responsible for maintaining proteins in their reduced state, in which process thioredoxin itself is oxidized and subsequently regenerated at the expense of NADPH via thioredoxin reductase.
Generally, ATP-dependent chaperones such as Hsp70 and Hsp90 assist with protein refolding, while ATP-independent chaperones known as small heat shock proteins (sHSPs) act as first responders by maintaining proteins in soluble forms to inhibit misfolding and to delay aggregation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com