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Consequently, cells able to maintain protein function in the alternating anaerobic:aerobic sludge cycling are favoured.
Stress responses classically involve heat shock proteins or molecular chaperones that maintain protein function or repair damage after cell injury.
All the four ω ratios are much lower than one (ω<0.2), indicating that MEF2A-D proteins are subject to strong purifying selection to maintain protein function.
Under this model, the estimate of ω was 0.19, indicating that NAT1 sequences have been subject to strong purifying selection to maintain protein function over time.
A low sequence homology can indicate that initial substitutions of amino acids had to be compensated for by secondary mutations to maintain protein function, resulting in constant conformational characteristics despite low sequence homology [ 27, 28].
When dN/ dS is less than 1, there is evidence that purifying selection has been a predominant force during evolution, acting to remove changes in amino acid sequence and maintain protein function.
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This can be achieved using site-specific labelling methods that exert maximum control over the number and site of modification(s) to the molecule, while still maintaining protein function.
This stands in contrast to other protein engineering techniques, like random point mutagenesis, in which the probability of maintaining protein function declines exponentially with increasing amino acid substitutions.
Protein surfaces rich in acidic residues probably play an essential role in maintaining protein function under alkaline conditions.
In their analysis, the authors predicted the impact of each variant on maintaining protein function using the predicting algorithm PolyPhen [19].
A majority of the Pgi coding sequence is conserved by strong purifying selection maintaining protein function.
More suggestions(15)
retained protein function
conserved protein function
retaining protein function
maintain protein activity
maintain protein turnover
maintain protein biosynthesis
maintain protein quality
maintain lung function
maintain protein balance
maintain protein expression
maintain protein solubility
maintain protein abundance
maintain protein sequence
maintain protein homoeostasis
maintain organ function
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