Sentence examples for maintain potent activity from inspiring English sources

Most modified oxazolidinone antibiotics keep the B-ring to maintain potent activity.

Thus, although single functional group removals from the vinblastine lower subunit typically result in pronounced and additive losses in activity, two unprecedented deep-seated structural changes to the core structure were found that maintain potent activity.

These compounds maintain potent IRAK4 activity and desirable ligand efficiency.

Compounds (II) 4a, 4d, 4f, 4j, 4l and 4n showed potent antiproliferative activity at sub-micromolar or nanomolar concentrations against SGC-7901, and9 and HT-1080 cell lines, indicating that the bioisosteric replacement of the carbonyl group and B-ring of SMART and ABI with a 5,5-fused-heterocycle scaffold successfully maintained potent antiproliferative activity.

While introduction of a third phosphate maintains potent agonist activity, the pyrophosphate region of cADPR is demonstrably sensitive to conservative modifications: a methylenebisphosphonate substitution is less active and sulphur or selenium-substituted pyrophosphates demonstrate contrasting activities between diastereoisomers in ether-substituted analogues.

Based on the proposed mechanism of bioactivation and structure activity relationships, design efforts led to N- pyridin-2-yl) arylsulfoN- pyridin-2-yl 18 aN- pyridin-2-yltaiN- pyridin-2-ylhydroxysteroid dehydrogenarylsulfonamidesity, suched exquisite phasmacokinetic profiles, and were negative in the reactive metabolite assay.

Additionally, HF maintained the weak activity against HaCaT cells, promoted a six-fold reduction in TGI value against the melanoma line compared to EEGP, and presented potent activity against prostate and ovarian tumors.

It has a potent activity against Myc.

Compound (2) also showed potent activity against butyryl cholinesterase.

Histatin-5 specifically has exhibited potent activity against C. albicans.

Compound 11c showed the most potent activity.