Sentence examples for maintain potent from inspiring English sources

People like Lee Krasner and Jackson Pollock Sylvia Wald and Po Kimm; and more recently, Gary Stephan and Suzanne Joelson are three examples of artist couples where both individuals maintain potent careers.

These compounds maintain potent IRAK4 activity and desirable ligand efficiency.

The question arises as to the general nature and the versatility of this minimal activator motif and whether smaller ligands can be designed which maintain potent activation function.

We sequentially passaged these constructs and analyzed their genetic stability by qPCR, and concluded that rMVA expressing multiple antigens using the mH5 promoter exhibit remarkable genetic stability and maintain potent immunogenicity after serial passage.

Most modified oxazolidinone antibiotics keep the B-ring to maintain potent activity.

Thus, although single functional group removals from the vinblastine lower subunit typically result in pronounced and additive losses in activity, two unprecedented deep-seated structural changes to the core structure were found that maintain potent activity.

Compounds (II) 4a, 4d, 4f, 4j, 4l and 4n showed potent antiproliferative activity at sub-micromolar or nanomolar concentrations against SGC-7901, and9 and HT-1080 cell lines, indicating that the bioisosteric replacement of the carbonyl group and B-ring of SMART and ABI with a 5,5-fused-heterocycle scaffold successfully maintained potent antiproliferative activity.

Based on the proposed mechanism of bioactivation and structure activity relationships, design efforts led to N- pyridin-2-yl) arylsulfoN- pyridin-2-yl 18 aN- pyridin-2-yltaiN- pyridin-2-ylhydroxysteroid dehydrogenarylsulfonamidesity, suched exquisite phasmacokinetic profiles, and were negative in the reactive metabolite assay.

The data indicate that EPA at 0.1 and 1 μM maintains potent efficacy at approximately 75% throughout the 5-day treatment period.

To this end, our findings suggest that increased luminal levels of butyrate could complement 5-ASA in promoting remission whilst maintaining potent chemopreventive effects against tumorigenesis.

More importantly, after being treated with several harsh conditions including boiling, low/high pH (pH = 1/13), extended storage, or freeze-thaw cycles, miRNAs in sera still maintained potent intrinsic stability as expected [ 60].