Sentence examples for maintain potency from inspiring English sources

These changes were designed to maintain potency and selectivity while inducing changes in physical properties leading to improved pharmacokinetics in three species.

Second, '70% maintain potency etc': It is slightly difficult to follow from the paper how many were in the group assessed, possibly due to a typo.

88 In short, the design of HIV protease inhibitors that maintain potency and eliminate side effects is a long-term exploring process.

Structural studies of neutralizing antibodies in complex with their peptide targets is starting to reveal how some antibodies can maintain potency in the face of viral evolution.

How feasible is it in practice to engineer antibodies that maintain potency against membrane-bound targets while having a reduced affinity for the soluble receptor is an open question.

MK-5172, a novel P2-P4 quinoxaline macrocyclic peptide, maintained potency across a genetically diverse panel of genotype 1a and 1b sequences from plasma of HCV-infected patients.

The replacement of the secondary benzylamino group with a phenylcyclopropylamino group maintained potency on BACE-1, while P-glycoprotein-mediated efflux was significantly reduced and brain permeation improved.

Chemical modifications of potent peptide inhibitors, such as peptoids and Nα-methylated amino acids, may overcome these drawbacks, while maintaining potency.

Another method, using residue mapping on evolutionary branches yielded peptides that had maintained potency towards the receptor and also showed increased stability.

Compounds 3, 4, and 5 were synthesized and found to be potent DPP-4 inhibitors, in particular 4 and 5 are designed to be highly selective against off-target DASH enzymes while maintaining potency on DPP-4.

Studies with drug resistant mutants showed that GNF-2 maintains potency against a subset of the clinically relevant imatinib-resistant Bcr-Abl mutants (e.g., E255V, Y253H), but was surprisingly much weaker against the T315I gatekeeper mutant [24].