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The initial labeling proportions amongst the two partitions are obtained from the day 10 predictions in stage 2 so that we maintain parameter integrity between the three different estimate regions.
It might be due to the capability to maintain parameter diversities with higher dS values.
In each iteration process, we have newly implemented a calculation using a parameter called dS to maintain parameter diversities.
We examined the effect of dS values on the convergence in this system, which was newly introduced in the algorithm to maintain parameter diversities as explained in the Methods section, and the calculation with dS of 0 is identical to the original CNM algorithm.
After improvements in the original CNM algorithm to maintain parameter diversities, a feasible solution space was successfully estimated for 55 or 56 parameters in the irinotecan PBPK model, within ten iterations, 3000 virtual samples, and in 15 minutes (Intel Xeon E5-1620 3.60GHz × 1 or Intel Core i7-870 2.93GHz × 1).
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(2) Different potentials for maintaining parameter difference are found for different airflow patterns.
These results suggest the importance of maintaining parameter diversities in performing CNM using the dS algorithm, while further investigations should be needed to rationally determine feasible dS values in other cases.
The maintained parameters for the fittings are displayed in Table 1. Figure 1 Production of the mycotoxins tenuazonic acid (TA) ( a ), alternariol (AOH) and alternariol monomethylether (AME) ( b ) and consumption of the nutrients glucose, nitrate and ammonium ( a, b ) with A. alternata DSM 12633 in a 2 L bioreactor.
For all parameter perturbations which maintain the parameter values within the shaded area in Fig. 7, both variables are singular and locked to their threshold, and robustness is preserved.
It is reliable to evaluate the potential of airflow patterns to maintain a parameter difference.
(3) It is difficult to maintain a parameter difference between two neighboring zones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com