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Two-sided tests will be used with Bonferroni-adjustment to maintain overall Type I error for this secondary aim at 0.05.
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P values adjusted to maintain overall 5% type 1 error rate across seven comparisons; 95% confidence intervals not adjusted.
Similar analysis of wild type foregut shows that endogenous RAR alpha activity is required to maintain overall RA signaling, and to refine the RAR beta effects in the lung field.
Overall, pyrogallol helped to maintain overall quality attributes and reduced quality-related physiological and biochemical activities.
Interestingly, genetically manipulating seed storage proteins in soybean, using RNA interference or mutation results in rebalancing of the proteome thereby maintaining overall wild-type levels of overall seed storage proteins [ 35, 36].
We adopted O'Brien-Fleming boundaries for discontinuation, and therefore maintain an overall type I error rate of 5%.
Zhang has advocated the selection of a primary endpoint and several secondary endpoints as a possible method to maintain the overall type I error rate [ 34].
To maintain an overall type I error rate of 0.05, each test of association with complete pathologic response was considered significant if P<0.005.
However, to address concerns regarding multiple testing, we also provide the p-values required to maintain an overall type I error bound of 0.05 after adjustment for multiple comparisons according to Holm (Aickin and Gensler 1996).
The stopping rule for the study on the basis of efficacy will be a nominal significance level of p = 0.003 (3 standard deviations) to maintain an overall Type I error probability of 5%.
The co-primary endpoints were analysed sequentially (ACR20 response at week 14 first and HAQ-DI at week 24 second) to maintain an overall type I error rate of 0.05.
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