Since the levels of POLRMT were slightly decreased with normal or slightly elevated levels of mt-mRNA, we assessed the stability of transcripts to see if the half-lives were extended to compensate for reduced synthesis in order to maintain normal steady state levels.
This redistribution causes a titration of the H3K27me3 mark from its endogenous sites, including the X chromosomes, and an inability to maintain normal gene expression states 138 138 138.
Finally, and in line with the previous suggestion, replication stalling might induce an increased rate of mitochondrial (DNA) turnover, for example, via mitophagy (see also 26), combined with an increased rate of replication in order to maintain normal mtDNA steady-state levels.
We use the concept of a threshold to recognize at a phenomenological level that some values of underlying physiological states maintain normal control and function, whereas others lead to lack of control and dysfunction that is discontinuous with the range of normal variation, even though the magnitude of the excursion from normal states may vary among cases.
In turn, the cell promotes the Lis1 effector, which enters the Active state to maintain normal association with the fiber.
124 Promotion of motor activity may thus be one important function of orexin, and this orexin-induced activity may be coupled strongly to behavioral state to maintain normal motor tone during periods of emotional or physical stress.
These observations are in agreement with previous results demonstrating a role for Epe1 in regulating H3K9me spreading at natural centromeres and fine-tuning this epigenetic state to maintain normal chromosome segregation [ 164– 164].
Recent studies in NaPi-IIb knockout mice have confirmed that this transport protein plays a significant role in intestinal phosphate absorption and is critical in the proposed feed-forward mechanism between the small intestine and kidney, which helps to maintain normal phosphate balance and steady-state plasma phosphate concentrations.
With such wide spectrum of nuclear receptors, which play a major role in maintaining normal physiological state and affect as diverse processes as development, reproduction, general metabolism, residing in Alus, it therefore becomes imperative to screen for variations in these sites.
Dehydration tolerance is defined as the relative capacity to maintain normal function even in a (partially) dehydrated state, which is also viewed as a secondary defense against desiccation.
